Gu He Selected Research

Therapeutics

12/2023	Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy.
10/2023	Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy.
1/2023	Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.
1/2023	The biological role and immunotherapy of gangliosides and GD3 synthase in cancers.
11/2022	Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
10/2022	Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors.
1/2022	Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions.
1/2022	Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity.
12/2021	Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy.
1/2021	Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole-Based RalA Inhibitors Against Hepatocellular Carcinoma.

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Gu He Research Topics

Disease

55	Neoplasms (Cancer) 04/2024 - 12/2010
9	Breast Neoplasms (Breast Cancer) 01/2018 - 10/2014
6	Carcinogenesis 12/2023 - 09/2017
5	Inflammation (Inflammations) 01/2023 - 01/2019
5	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 09/2010
4	Arthritis (Polyarthritis) 01/2024 - 03/2016
3	Ovarian Neoplasms (Ovarian Cancer) 01/2023 - 05/2013
3	Infections 01/2023 - 09/2014
3	Rosacea (Acne Rosacea) 01/2023 - 01/2019
3	Neoplasm Metastasis (Metastasis) 01/2021 - 11/2012
3	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 01/2019
3	Melanoma (Melanoma, Malignant) 12/2019 - 09/2014
2	Asthma (Bronchial Asthma) 01/2024 - 01/2018
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2023 - 06/2023
2	Skin Diseases (Skin Disease) 01/2023 - 01/2022
2	Renal Cell Carcinoma (Grawitz Tumor) 12/2021 - 01/2019
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020 - 01/2019
2	Acne Vulgaris 07/2019 - 01/2019
2	Nasopharyngeal Carcinoma 01/2019 - 09/2017
2	Carcinoma (Carcinomatosis) 01/2019 - 05/2013
2	Bacterial Infections (Bacterial Infection) 11/2018 - 01/2017
1	B-Cell Lymphoma (Lymphoma, B Cell) 04/2024
1	Nervous System Diseases (Neurological Disorders) 03/2024
1	Ulcerative Colitis 01/2024
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2024
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2024
1	Fibrosis (Cirrhosis) 12/2023
1	Weight Loss (Weight Reduction) 12/2023
1	Lung Injury 12/2023
1	Adenocarcinoma of Lung 12/2023
1	Stomach Neoplasms (Stomach Cancer) 01/2023
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2023
1	Bullous Pemphigoid (Pemphigoid) 01/2023
1	Atopic Dermatitis (Atopic Eczema) 01/2023
1	Urinary Bladder Neoplasms (Bladder Cancer) 11/2022

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 03/2024 - 06/2015
6	MicellesIBA 11/2018 - 04/2011
4	Therapeutic UsesIBA 06/2023 - 10/2014
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2022 - 10/2014
4	Phosphotransferases (Kinase)IBA 07/2020 - 01/2018
4	CholesterolIBA 11/2018 - 04/2011
3	LipidsIBA 03/2024 - 01/2014
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2023 - 12/2019
3	spirooxindoleIBA 01/2023 - 08/2020
3	pyrimidineIBA 01/2023 - 01/2019
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2023 - 01/2017
3	Membrane Proteins (Integral Membrane Proteins)IBA 11/2022 - 09/2017
3	Protein Kinases (Protein Kinase)IBA 10/2022 - 01/2019
3	Small Interfering RNA (siRNA)IBA 12/2021 - 12/2013
3	Competitive Endogenous RNAIBA 04/2021 - 09/2017
3	Long Noncoding RNAIBA 04/2021 - 09/2017
3	SpirooxindolesIBA 08/2020 - 08/2015
3	Peptides (Polypeptides)IBA 05/2018 - 10/2016
3	Amino Acids FDA Link 01/2018 - 01/2014
3	Liposomes (Liposome)IBA 01/2017 - 09/2010
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 01/2022
2	TOR Serine-Threonine KinasesIBA 11/2022 - 07/2019
2	Drug CombinationsIBA 01/2022 - 01/2021
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2022 - 01/2020
2	Messenger RNA (mRNA)IBA 04/2021 - 01/2019
2	RNA (Ribonucleic Acid)IBA 04/2021 - 01/2020
2	Elongation Factor 2 KinaseIBA 01/2021 - 01/2018
2	LigandsIBA 01/2019 - 10/2016
2	EpitopesIBA 05/2018 - 01/2018
2	VaccinesIBA 05/2018 - 12/2015
2	Protein Subunit VaccinesIBA 05/2018 - 01/2018
2	LipopeptidesIBA 05/2018 - 01/2017
2	EnzymesIBA 01/2018 - 03/2016
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2017 - 02/2017
2	BL-EI001IBA 02/2017 - 03/2015
2	Folic Acid (Vitamin M)FDA LinkGeneric 12/2013 - 05/2013
2	monomethoxypolyethylene glycol (MPEG)IBA 05/2013 - 10/2012
2	Ethylene Glycol (Monoethylene Glycol)IBA 10/2012 - 04/2011
1	Thioredoxin-Disulfide ReductaseIBA 04/2024
1	MetalsIBA 04/2024
1	LipocalinsIBA 03/2024
1	PolyphenolsIBA 01/2024
1	Dasatinib (BMS 354825)FDA Link 12/2023
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2023
1	Discoidin Domain ReceptorsIBA 12/2023
1	Beclin-1IBA 12/2023
1	Tubulin ModulatorsIBA 10/2023
1	Histone Deacetylase InhibitorsIBA 10/2023
1	trioctyl phosphine oxide (TOPO)IBA 10/2023
1	Histone MethyltransferasesIBA 01/2023
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 01/2023
1	Activating Transcription FactorsIBA 01/2023
1	GangliosidesIBA 01/2023
1	Interleukin-18 (Interleukin 18)IBA 01/2023
1	AmmoniaIBA 01/2022
1	Sulfur DioxideIBA 01/2022
1	interleukin-22 receptor (IL-22R)IBA 01/2022
1	Interleukin-22 (IL-22)IBA 01/2022
1	HydrogenIBA 01/2022
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2022
1	Carbon MonoxideIBA 01/2022

Therapy/Procedure

42	Therapeutics 12/2023 - 09/2010
4	Drug Therapy (Chemotherapy) 07/2019 - 06/2011
2	Immunotherapy 01/2023 - 05/2018
1	Photochemotherapy (Photodynamic Therapy) 01/2023